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KMID : 1009020180160010109
Clinical Psychopharmacology and Neuroscience
2018 Volume.16 No. 1 p.109 ~ p.113
Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-like Activity: A Case Report
Kim So-Yeon

Um Yoo-Hyun
Lim Sung-Chul
Jeong Jong-Hyun
Abstract
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related LE who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded.
KEYWORD
Anti-LGI-1 antibody encephalitis, Neuropsychiatric symptoms, Steroid therapy
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